Endocrine Abstracts

There are few valid data that describe the frequency of comorbidity in primary hypothyroidism patients seen in family practice. This study aimed to investigate the prevalence of comorbidities and their association with elevated (≥4.0%) thyroid-stimulating hormone (TSH) using a large sample of hyhpothyroidism patients from primary care practices.Materials and methods: A cross-sectional study in which multivariate logistic regression was applied to e...

Polymorphism of the vitamin D receptor (VDR) gene has been reported to play a major role in variations for genetic regulation of bone mass. The current study is an attempt to examine the association of these variations with osteoporosis in patients with hypothyroidism. The purpose of this study was to determine distribution of genotypes and allelic frequencies of polymorphism of rs731236 (C+61968t; TaqI) VDR gene, and also risk of development and association with risk factors ...

There is increasing interest in the role of vitamin D deficiency in a number of chronic health problems including autoimmune diseases. The aetiology and pathogenesis of most autoimmune disorders remain obscure and a number of factors have been implicated in their pathogenesis, one of the most recent agents found to be associated with autoimmunity is vitamin 25(OH)D. The aim of the study was to assess total vitamin 25(OH)D status in patients with autoimmune thyroiditis with sub...

Background: Metformin is the most widely used oral antihyperglycaemic drug, but it may lower B12 status, which could have important clinical implications.Aim: To study serum Vitamin B12 levels in patients with type 2 diabetes mellitus who were receiving metformin and compared them to those never treated with metformin.Materials and methods: A total of 60 patients with type 2 DM (group 1, n = 35, r...

Background: Over the past decade, numerous non-skeletal diseases have been reported to be associated with vitamin D deficiency including autoimmune thyroid pathology.Aim: The aim of the study is to evaluate the effects of vitamin D supplementation on insulin resistance in hypothyroidism.Materials and methods: Forty-seven participants, 32–74 years old, including 39 women (82.9%) and 8 men (17.1%) took part in the study. Serum T...

Background and aimVitamin D may affect glucose homeostasis, vitamin D levels having been found to be inversely related to glycosylated hemoglobin (HbA1c) levels in type 2 DM. With the scarcity of the regarding data in Ukraine, the aim of this study was to assess the relationship between hypovitaminosis D and glycemic control in type 2 DM women of reproductive age.Material and methodsTo test the hypothesis tha...

Iodine is important in both thyroid function and human metabolism. The roles of iodine intake on the metabolic syndrome (MetS) etiology remain controversial.The aim of this study: Was to investigate the relationship between iodine status and MetS and its components. 371 subjects aged ≥20 years were included.Materials and methods: The presence of MetS was defined according to the Adult Treatment Panel (ATP) III criteria. The p...

Introduction: Decrease in thyroid hormones (TH) levels is associated with reduced blood flow to kidneys and decreased glomerular filtration rate (GFR) along with alteration of tubular reabsorption.Deiodinase type 1 is an enzyme that is active in liver and kidneys and plays an important role in TH metabolism.The aim of the research was to study the dependence of markers of renal function on C/T polymorphism in the DIO 1 gene in pati...

Introduction: Chronic kidney disease (CKD) is one of the leading causes ofdisability and mortality in patients with diabetes mellitus. Existence of specific phenotypes of diabetic kidney disease (DKD) is established nowadays. The prevalence of the classic albuminuric phenotype has decreased by 24% over the past decade (NHANES).The purpose of our work was to investigate the phenotypic features of DKD depending on the type of diabetes.<p class="abstext...

Introduction: Diabetes mellitus is known as a factor of cognitive impairment. The risk of dementia in patients with type 2 diabetes mellitus (T2DM) increases almost twice. The results of epidemiological, visualization and autopsy studies showed the presence of both cerebrovascular and neurodegenerative mechanisms of brain lesions. Cell death of key substrates – neurons and endothelial cells lays in the basis of the formation of cerebral disorders. Granzyme B (GrB) is a s...